Medical Policy Recombinant Human Bone Morphogenetic Protein (rhBMP) for Bone Fusion
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چکیده
*(Unfeasible is defined as autograft is no longer available because of prior use or insufficient tissue or the candidate is unacceptable because of any of the following reasons obesity, over 65 years of age, morbidity preventing harvesting at autograft donor site (infection, fracture), excessive risk of anatomic disruption from harvesting, osteoporosis, concurrent medical conditions and co-morbidities that increase risk of autograft.)
منابع مشابه
Analysis of Recombinant Human Bone Morphogenetic Protein-2 Use in the Treatment of Lumbar Degenerative Spondylolisthesis
Study Design Retrospective database review. Objective To identify trends of the recombinant human bone morphogenetic protein-2 (rhBMP-2) use in the treatment of lumbar degenerative spondylolisthesis (LDS). Methods PearlDiver Patient Record Database was used to identify patients who underwent lumbar fusion for LDS between 2005 and 2011. The distribution of bone morphogenetic protein use rate (BR...
متن کاملLongitudinal performance of polycaprolactone-based scaffold plus recombinant human morphogenetic protein-2 (rhBMP-2) in large preclinical animal model: 6- versus 12 months
Objectives There is strong current interest in the use of biodegradable scaffolds in combination with bone growth factors as a valuable alternative to the current gold standard autograft in spinal fusion surgery (Yong et al. 2013). Here we report on 6vs 12month data set evaluating the longitudinal performance of a CaP coated polycaprolactone (PCL) scaffold loaded with recombinant human bone mor...
متن کاملComplications of Anterior Cervical Fusion using a Low-dose Recombinant Human Bone Morphogenetic Protein-2
OBJECTIVE There are several reports, which documented a high incidence of complications following the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in anterior cervical fusions (ACFs). The objective of this study is to share our experience with low-dose rhBMP-2 in anterior cervical spine. METHODS We performed a retrospective analysis of 197 patients who underwent anterior ce...
متن کاملComparison of rhBMP-2 versus Autogenous Iliac Crest Bone Graft for 2-Level Anterior Cervical Discectomy and Fusion for Cervical Spondylotic Myelopathy
BACKGROUND Few studies have examined the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) in 2-level anterior cervical discectomy and fusion (ACDF). The purpose of this study was to compare the outcomes in a series of patients with CSM treated with 2-level ACDF with or without rhBMP-2. MATERIAL AND METHODS The retrospective study included a total of 146 patients with CSM. ...
متن کاملMeta-analysis of the Impact of Patient Characteristics on Estimates of Effectiveness and Harms of Recombinant Human Bone Morphogenetic Protein-2 in Lumbar Spinal Fusion.
STUDY DESIGN Meta-analysis of individual patient data from randomized controlled trials of recombinant human bone morphogenetic protein-2 (rhBMP-2) in lumbar spinal fusion. OBJECTIVE To determine how patient characteristics impact estimates of effectiveness and harms of rhBMP-2 versus iliac crest bone graft (ICBG) in lumbar spinal fusion. SUMMARY OF BACKGROUND DATA Patient characteristics a...
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